The Egocentric Comorbidity Network on Malignant neoplasm of gallbladder and extrahepatic bile ducts


Disease Info.
ICD-9: 156
Disease ID: 107
Disease Name: Malignant neoplasm of gallbladder and extrahepatic bile ducts
Descriptives of the sampled nested cases-control dataset
Total individual= 1495
Case:Control = 299 : 1196 ( 1 : 4 )
No. of control with zero baseline= 378
No. of select variables= 300
Fitted coefficients in conditional logistic model (p<0.05 only)
*Progression links allowed are marked in red
coef exp(coef) se(coef) z Pr(>|z|) name sig
9.432 12482.832 2.894 3.259 0.001 Disorders of the pituitary gland and its hypothalamic control ***
6.101 446.250 1.756 3.474 0.001 Malignant neoplasm of bladder ***
5.654 285.368 2.049 2.760 0.006 Excessive vomiting in pregnancy **
4.636 103.122 1.404 3.303 0.001 Other diseases of blood and blood-forming organs ***
4.160 64.101 1.510 2.756 0.006 Conduction disorders **
3.070 21.550 1.460 2.102 0.036 Hypotension *
3.018 20.455 0.866 3.484 0.000 Hypertensive renal disease ***
2.708 15.004 1.169 2.316 0.021 Corns and callosities *
2.194 8.971 0.635 3.457 0.001 Hydronephrosis ***
2.089 8.080 0.378 5.528 0.000 Malignant neoplasm of liver and intrahepatic bile ducts ***
1.845 6.326 0.607 3.040 0.002 Malignant neoplasm of pancreas **
1.705 5.504 0.632 2.698 0.007 Group B streptococcus infections of unspecified site **
1.669 5.308 0.735 2.270 0.023 Liver abscess and sequelae of chronic liver disease *
1.586 4.885 0.371 4.273 0.000 Secondary malignant neoplasm of respiratory and digestive systems ***
1.533 4.634 0.622 2.464 0.014 Malignant neoplasm of female breast *
1.219 3.384 0.399 3.055 0.002 Disorders of menstruation and other abnormal bleeding from female genital tract **
1.177 3.246 0.463 2.544 0.011 Glaucoma *
1.001 2.720 0.357 2.804 0.005 Disorders of muscle, ligament and fascia **
0.983 2.673 0.371 2.651 0.008 Duodenal ulcer **
0.798 2.221 0.356 2.242 0.025 Gout *
0.729 2.074 0.304 2.398 0.016 Diabetes mellitus *
0.716 2.047 0.313 2.286 0.022 Pruritus and related conditions *
0.692 1.998 0.320 2.162 0.031 Symptoms involving skin and other integumentary tissue *
0.671 1.957 0.265 2.534 0.011 Gastritis and duodenitis *
0.598 1.818 0.248 2.408 0.016 Other symptoms involving abdomen and pelvis *
0.587 1.798 0.285 2.058 0.040 Chronic liver disease and cirrhosis *
-0.608 0.544 0.300 -2.030 0.042 Symptoms involving respiratory system and other chest symptoms *
-0.743 0.476 0.268 -2.774 0.006 Other and unspecified disorder of joint **
-1.077 0.341 0.459 -2.349 0.019 Other diseases of upper respiratory tract *
-1.154 0.315 0.503 -2.292 0.022 Other disorders of eyelids *
-1.911 0.148 0.789 -2.421 0.015 Ill-defined descriptions and complications of heart disease *
-2.007 0.134 0.834 -2.407 0.016 Atherosclerosis *
-2.248 0.106 1.091 -2.060 0.039 Nonspecific findings on examination of blood *
-2.649 0.071 0.847 -3.129 0.002 Chronic airways obstruction, not elsewhere classified **
-2.979 0.051 1.443 -2.064 0.039 Other disorders of arteries and arterioles *
-3.546 0.029 1.782 -1.990 0.047 Disorders of optic nerve and visual pathways *
-5.822 0.003 2.365 -2.462 0.014 Malignant neoplasm of kidney and other and unspecified urinary organs *
-6.249 0.002 3.127 -1.998 0.046 Nonspecific abnormal histological and immunological findings *
-7.595 0.001 2.932 -2.590 0.010 Obesity and other hyperalimentation **
-11.816 0.000 2.958 -3.994 0.000 Transient organic psychotic conditions ***
Age distribution of cases
Prevalence of exposure in the dataset per 100,000
*marked green when case > control
case control overall name
72575.25 45317.73 50769.23 General symptoms
58862.88 30602.01 36254.18 Gastritis and duodenitis
57525.08 37123.75 41204.01 Other and unspecified disorders of back
56856.19 38294.31 42006.69 Gingival and periodontal diseases
55518.39 22742.47 29297.66 Other symptoms involving abdomen and pelvis
54180.60 28428.09 33578.60 Functional digestive disorders, not elsewhere classified
52842.81 34113.71 37859.53 Other disorders of soft tissues
51839.46 26337.79 31438.13 Disorders of function of stomach
51170.57 34615.38 37926.42 Essential hypertension
50167.22 32859.53 36321.07 Diseases of hard tissues of teeth
45150.50 20986.62 25819.40 Peptic ulcer, site unspecified
44481.61 33695.65 35852.84 Osteoarthrosis and allied disorders
42809.36 27173.91 30301.00 Cataract
42809.36 26505.02 29765.89 Contact dermatitis and other eczema
42140.47 26755.85 29832.78 Symptoms involving respiratory system and other chest symptoms
41806.02 28678.93 31304.35 Symptoms involving head and neck
40468.23 22240.80 25886.29 Other noninfectious gastroenteritis and colitis
39799.33 21655.52 25284.28 Disorders of lipoid metabolism
37792.64 21739.13 24949.83 Other disorders of urethra and urinary tract
36789.30 12709.03 17525.08 Chronic liver disease and cirrhosis
34782.61 22073.58 24615.38 Diseases of pulp and periapical tissues
33444.82 22658.86 24816.05 Spondylosis and allied disorders
33110.37 25167.22 26755.85 Other and unspecified disorder of joint
32107.02 20066.89 22474.92 Neurotic disorders
28762.54 14297.66 17190.64 Diabetes mellitus
28428.09 16387.96 18795.99 Inflammatory disease of cervix, vagina and vulva
28093.65 19648.83 21337.79 Hypertensive heart disease
25418.06 18812.71 20133.78 Diseases of the oral soft tissues, excluding lesions specific for gingiva and tongue
25418.06 15886.29 17792.64 Peripheral enthesopathies and allied syndromes
25418.06 8695.65 12040.13 Symptoms involving skin and other integumentary tissue
25083.61 14632.11 16722.41 Vertiginous syndromes and other disorders of vestibular system
25083.61 15301.00 17257.53 Other forms of chronic ischemic heart disease
24749.16 15969.90 17725.75 Menopausal and postmenopausal disorders
24080.27 12959.87 15183.95 Pruritus and related conditions
24080.27 19397.99 20334.45 Other disorders of bone and cartilage
23076.92 13461.54 15384.62 Symptoms involving digestive system
22742.47 334.45 4816.05 Malignant neoplasm of liver and intrahepatic bile ducts
21404.68 17391.30 18193.98 Other disorders of synovium, tendon and bursa
19397.99 11287.63 12909.70 Allergic rhinitis
19397.99 11371.24 12976.59 Urticaria
19063.55 9615.38 11505.02 Gastric ulcer
18729.10 15301.00 15986.62 Other and unspecified arthropathies
18060.20 8612.04 10501.67 Symptoms involving urinary system
17725.75 250.84 3745.82 Secondary malignant neoplasm of respiratory and digestive systems
16387.96 5852.84 7959.87 Other and unspecified anemias
16387.96 7107.02 8963.21 Disorders of menstruation and other abnormal bleeding from female genital tract
16387.96 8695.65 10234.11 Symptoms involving cardiovascular system
16053.51 10033.44 11237.46 Chronic bronchitis
16053.51 4515.05 6822.74 Duodenal ulcer
16053.51 8946.49 10367.89 Disorders of muscle, ligament and fascia
16053.51 9782.61 11036.79 Dermatophytosis
15719.06 9113.71 10434.78 Intervertebral disc disorders
15384.62 7525.08 9096.99 Diseases of esophagus
14715.72 7357.86 8829.43 Gout
14715.72 10284.28 11170.57 Cardiac dysrhythmias
14715.72 7525.08 8963.21 Chronic pharyngitis and nasopharyngitis
14715.72 10117.06 11036.79 Other diseases and conditions of the teeth and supporting structures
13377.93 7190.64 8428.09 Special symptoms or syndromes not elsewhere classified
13043.48 7943.14 8963.21 Other disorders of cervical region
12709.03 9364.55 10033.44 Disorders of lacrimal system
12374.58 6020.07 7290.97 Other disorders of eye
12374.58 7107.02 8160.54 Heart failure
12040.13 6605.35 7692.31 Other retinal disorders
11705.69 9030.10 9565.22 Visual disturbances
10702.34 8026.76 8561.87 Asthma
10367.89 5602.01 6555.18 Angina pectoris
10033.44 7023.41 7625.42 Other diseases of upper respiratory tract
9699.00 4096.99 5217.39 Herpes zoster
9699.00 3511.71 4749.16 Hemorrhoids
9699.00 3678.93 4882.94 Viral hepatitis
8695.65 4347.83 5217.39 Glaucoma
8695.65 5602.01 6220.74 Disorders of refraction and accommodation
8695.65 2090.30 3411.37 Other disorders of liver
8026.76 1755.85 3010.03 Neoplasm of unspecified nature
8026.76 4096.99 4882.94 Nerve root and plexus disorders
8026.76 6270.90 6622.07 Other disorders of ear
7692.31 3678.93 4481.61 Physiological malfunction arising from mental factors
7357.86 1421.40 2608.70 Benign neoplasm of other parts of digestive system
7357.86 7274.25 7290.97 Other disorders of eyelids
6688.96 2759.20 3545.15 Uterine leiomyoma
6688.96 2090.30 3010.03 Atopic dermatitis and related conditions
6354.52 3344.48 3946.49 Senile and presenile organic psychotic conditions
6354.52 3846.15 4347.83 Other disorders of breast
6020.07 83.61 1270.90 Malignant neoplasm of pancreas
6020.07 4264.21 4615.38 Mononeuritis of upper limb and mononeuritis multiplex
6020.07 3762.54 4214.05 Other and ill-defined cerebrovascular disease
5685.62 3177.26 3678.93 Benign neoplasm of skin
5685.62 5936.45 5886.29 Other disorders of skin and subcutaneous tissue
5351.17 2508.36 3076.92 Affective psychoses
5351.17 3177.26 3612.04 Migraine
5351.17 4682.27 4816.05 Other diseases of endocardium
5016.72 167.22 1137.12 Secondary and unspecified malignant neoplasm of lymph nodes
4682.27 2675.59 3076.92 Benign neoplasm of breast
4682.27 2173.91 2675.59 Iron deficiency anemias
4682.27 3010.03 3344.48 Late effects of cerebrovascular disease
4682.27 3846.15 4013.38 Other diseases due to viruses and Chlamydiae
4347.83 752.51 1471.57 Malignant neoplasm of female breast
4347.83 1839.46 2341.14 Chronic renal failure
4347.83 3260.87 3478.26 Rheumatoid arthritis and other inflammatory polyarthropathies
4013.38 167.22 936.45 Liver abscess and sequelae of chronic liver disease
4013.38 1421.40 1939.80 Hydronephrosis
4013.38 2173.91 2541.81 Noninflammatory disorders of cervix
4013.38 2508.36 2809.36 Noninflammatory disorders of vagina
4013.38 2090.30 2474.92 Pain and other symptoms associated with female genital organs
4013.38 2508.36 2809.36 Other acquired deformity
3678.93 2006.69 2341.14 Parkinson's disease
3678.93 2675.59 2876.25 Hearing loss
3678.93 1086.96 1605.35 Disorders of uterus, not elsewhere classified
3678.93 3846.15 3812.71 Diseases of sebaceous glands
3678.93 4264.21 4147.16 Candidiasis
3344.48 1170.57 1605.35 Thyrotoxicosis with or without goiter
3344.48 1254.18 1672.24 Acute, but ill-defined, cerebrovascular disease
3344.48 2591.97 2742.47 Other peripheral vascular disease
3344.48 2341.14 2541.81 Other disorders of bladder
3010.03 1170.57 1538.46 Malignant neoplasm of colon
3010.03 83.61 668.90 Secondary malignant neoplasm of other specified sites
3010.03 1672.24 1939.80 Group B streptococcus infections of unspecified site
3010.03 2006.69 2207.36 Suppurative and unspecified otitis media
3010.03 3929.77 3745.82 Ill-defined descriptions and complications of heart disease
3010.03 2424.75 2541.81 Chronic sinusitis
3010.03 3595.32 3478.26 Chronic airways obstruction, not elsewhere classified
3010.03 919.73 1337.79 Gastrojejunal ulcer
3010.03 1254.18 1605.35 Other disorders of kidney and ureter
3010.03 1337.79 1672.24 Dermatitis due to substances taken internally
2675.59 250.84 735.79 Neoplasm of uncertain behavior of digestive and respiratory systems
2675.59 1337.79 1605.35 Other extrapyramidal disease and abnormal movement disorders
2675.59 1086.96 1404.68 Mononeuritis of lower limb
2675.59 2257.53 2341.14 Inflammatory and toxic neuropathy
2675.59 1672.24 1872.91 Erythematosquamous dermatosis
2675.59 1672.24 1872.91 Ankylosing spondylitis and other inflammatory spondylopathies
2675.59 836.12 1204.01 Nonspecific findings on examination of urine
2675.59 418.06 869.57 Other ill-defined and unknown causes of morbidity and mortality
2341.14 1254.18 1471.57 Simple and unspecified goiter
2341.14 919.73 1204.01 Other organic psychotic conditions (chronic)
2341.14 752.51 1070.23 Hemiplegia and hemiparesis
2341.14 1839.46 1939.80 Nonsuppurative otitis media and eustachian tube disorders
2341.14 501.67 869.57 Hypertensive renal disease
2341.14 1337.79 1538.46 Atherosclerosis
2341.14 1254.18 1471.57 Bronchiectasis
2341.14 585.28 936.45 Other disorders of stomach and duodenum
2341.14 2006.69 2073.58 Chronic glomerulonephritis
2341.14 752.51 1070.23 Other disorders of female genital organs
2341.14 2424.75 2408.03 Diffuse diseases of connective tissue
2341.14 2508.36 2474.92 Other derangement of joint
2341.14 1003.34 1270.90 Late effects of tuberculosis
2006.69 668.90 936.45 Malignant neoplasm of cervix uteri
2006.69 1923.08 1939.80 Other benign neoplasm of connective and other soft tissue
2006.69 1003.34 1204.01 Benign neoplasm of ovary
2006.69 2090.30 2073.58 Coronary occlusion without myocardial infarction
2006.69 1170.57 1337.79 Herpes simplex
2006.69 752.51 1003.34 Varicose veins of lower extremities
2006.69 585.28 869.57 Other diseases of lung
2006.69 1421.40 1538.46 Regional enteritis
2006.69 1755.85 1806.02 Other disorders of intestine
2006.69 1086.96 1270.90 Nephritis and nephropathy, not specified as acute or chronic
2006.69 418.06 735.79 Renal failure, unspecified
2006.69 1003.34 1204.01 Benign mammary dysplasias
2006.69 1505.02 1605.35 Disorders of sweat glands
2006.69 1337.79 1471.57 Nonspecific abnormal results of function studies
2006.69 1839.46 1872.91 Dermatomycosis, other and unspecified
1672.24 585.28 802.68 Other disorders of pancreatic internal secretion
1672.24 836.12 1003.34 Other deficiency anemias
1672.24 1505.02 1538.46 Other paralytic syndromes
1672.24 1755.85 1739.13 Hereditary and idiopathic peripheral neuropathy
1672.24 1003.34 1137.12 Other disorders of circulatory system
1672.24 250.84 535.12 Other hernia of abdominal cavity without mention of obstruction or gangrene
1672.24 1003.34 1137.12 Genital prolapse
1672.24 919.73 1070.23 Erythematous conditions
1672.24 334.45 602.01 Corns and callosities
1672.24 1755.85 1739.13 Internal derangement of knee
1672.24 1254.18 1337.79 Other congenital musculoskeletal anomalies
1672.24 1839.46 1806.02 Symptoms involving nervous and musculoskeletal systems
1672.24 1170.57 1270.90 Nonspecific findings on examination of blood
1337.79 83.61 334.45 Malignant neoplasm of bladder
1337.79 1086.96 1137.12 Other benign neoplasm of uterus
1337.79 1337.79 1337.79 Nontoxic nodular goiter
1337.79 1254.18 1270.90 Acquired hypothyroidism
1337.79 668.90 802.68 Other disorders of thyroid
1337.79 585.28 735.79 Pulmonary tuberculosis
1337.79 501.67 668.90 Hereditary hemolytic anemias
1337.79 1337.79 1337.79 Depressive disorder, not elsewhere classified
1337.79 83.61 334.45 Psychic factors associated with diseases classified elsewhere
1337.79 836.12 936.45 Facial nerve disorders
1337.79 919.73 1003.34 Disorders of iris and ciliary body
1337.79 83.61 334.45 Chronic pulmonary heart disease
1337.79 1170.57 1204.01 Dentofacial anomalies, including malocclusion
1337.79 334.45 535.12 Diseases and other conditions of the tongue
1337.79 167.22 401.34 Peritonitis
1337.79 1003.34 1070.23 Nephrotic syndrome
1337.79 836.12 936.45 Disorders resulting from impaired renal function
1337.79 668.90 802.68 Endometriosis
1337.79 836.12 936.45 Noninflammatory disorders of ovary, fallopian tube and broad ligament
1337.79 250.84 468.23 Hemorrhage in early pregnancy
1337.79 1086.96 1137.12 Chronic ulcer of skin
1337.79 418.06 602.01 Osteomyelitis,periostitis and other infections involving bone
1337.79 1254.18 1270.90 Other mycoses
1003.34 418.06 535.12 Malignant neoplasm of rectum, rectosigmoid junction, and anus
1003.34 83.61 267.56 Malignant neoplasm without specification of site
1003.34 250.84 401.34 Disorders of adrenal glands
1003.34 1337.79 1270.90 Other cerebral degenerations
1003.34 83.61 267.56 Other diseases of spinal cord
1003.34 752.51 802.68 Trigeminal nerve disorders
1003.34 1003.34 1003.34 Retinal detachments and defects
1003.34 1755.85 1605.35 Corneal opacity and other disorders of cornea
1003.34 334.45 468.23 Hypertensive heart and renal disease
1003.34 83.61 267.56 Conduction disorders
1003.34 334.45 468.23 Varicose veins of other sites
1003.34 418.06 535.12 Chronic disease of tonsils and adenoids
1003.34 501.67 602.01 Chronic laryngitis and laryngotracheitis
1003.34 668.90 735.79 Emphysema
1003.34 334.45 468.23 Disorders of tooth development and eruption
1003.34 668.90 735.79 Diseases of the jaws
1003.34 334.45 468.23 Acute renal failure
1003.34 585.28 668.90 Viral and chlamydial infection in conditions classified elsewhere and of unspecified site
1003.34 250.84 401.34 Other complications of pregnancy, not elsewhere classified
1003.34 1170.57 1137.12 Diseases of hair and hair follicles
1003.34 1086.96 1070.23 Curvature of spine
668.90 668.90 668.90 Malignant neoplasm of trachea, bronchus and lung
668.90 83.61 200.67 Malignant neoplasm of brain
668.90 334.45 401.34 Benign neoplasm of respiratory and intrathoracic organs
668.90 585.28 602.01 Benign neoplasm of other and unspecified sites
668.90 668.90 668.90 Carcinoma in situ of breast and genitourinary system
668.90 167.22 267.56 Disorders of parathyroid gland
668.90 334.45 401.34 Ovarian dysfunction
668.90 250.84 334.45 Disorders of mineral metabolism
668.90 250.84 334.45 Diseases of white blood cells
668.90 167.22 267.56 Other diseases of blood and blood-forming organs
668.90 668.90 668.90 Schizophrenic disorders
668.90 83.61 200.67 Personality disorders
668.90 585.28 602.01 Acute reaction to stress
668.90 668.90 668.90 Epilepsy
668.90 585.28 602.01 Other conditions of brain
668.90 1421.40 1270.90 Disorders of the globe
668.90 668.90 668.90 Disorders of optic nerve and visual pathways
668.90 167.22 267.56 Other disorders of tympanic membrane
668.90 167.22 267.56 Other disorders of middle ear and mastoid
668.90 250.84 334.45 Rheumatic diseases of aortic valve
668.90 250.84 334.45 Aortic aneurysm and dissection
668.90 250.84 334.45 Arterial embolism and thrombosis
668.90 919.73 869.57 Other disorders of arteries and arterioles
668.90 418.06 468.23 Other venous embolism and thrombosis
668.90 250.84 334.45 Inguinal hernia
668.90 167.22 267.56 Abnormality of organs and soft tissues of pelvis
668.90 83.61 200.67 Bullous dermatoses
668.90 752.51 735.79 Psoriasis and similar disorders
668.90 1421.40 1270.90 Other hypertrophic and atrophic conditions of skin
668.90 1337.79 1204.01 Other dermatoses
668.90 334.45 401.34 Diseases of nail
668.90 167.22 267.56 Arthropathy associated with infections
668.90 167.22 267.56 Other acquired deformities of limbs
668.90 167.22 267.56 Nonspecific abnormal histological and immunological findings
668.90 83.61 200.67 Other nonspecific abnormal findings
668.90 919.73 869.57 Acariasis
334.45 83.61 133.78 Malignant neoplasm of stomach
334.45 83.61 133.78 Malignant neoplasm of body of uterus
334.45 167.22 200.67 Malignant neoplasm of ovary and other uterine adnexa
334.45 334.45 334.45 Malignant neoplasm of kidney and other and unspecified urinary organs
334.45 83.61 133.78 Other malignant neoplasms of lymphoid and histiocytic tissue
334.45 250.84 267.56 Benign neoplasm of lip, oral cavity and pharynx
334.45 83.61 133.78 Benign neoplasm of bone and articular cartilage
334.45 334.45 334.45 Lipoma
334.45 334.45 334.45 Benign neoplasm of brain and other parts of nervous system
334.45 250.84 267.56 Thyroiditis
334.45 83.61 133.78 Disorders of the pituitary gland and its hypothalamic control
334.45 418.06 401.34 Other endocrine disorders
334.45 585.28 535.12 Other and unspecified disorders of metabolism
334.45 501.67 468.23 Obesity and other hyperalimentation
334.45 250.84 267.56 Disorders involving the immune mechanism
334.45 83.61 133.78 Coagulation defects
334.45 501.67 468.23 Purpura and other hemorrhagic conditions
334.45 334.45 334.45 Transient organic psychotic conditions
334.45 167.22 200.67 Nondependent abuse of drugs
334.45 668.90 602.01 Adjustment reaction
334.45 334.45 334.45 Specific nonpsychotic mental disorder due to organic brain damage
334.45 83.61 133.78 Other specified mental retardation
334.45 167.22 200.67 Disorders of the autonomic nervous system
334.45 83.61 133.78 Infantile cerebral palsy
334.45 167.22 200.67 Disorders of other cranial nerves
334.45 501.67 468.23 Myoneural disorders
334.45 83.61 133.78 Muscular dystrophies and other myopathies
334.45 83.61 133.78 Rheumatic diseases of mitral valve
334.45 418.06 401.34 Diseases of mitral and aortic valves
334.45 418.06 401.34 Secondary hypertension
334.45 250.84 267.56 Old myocardial infarction
334.45 83.61 133.78 Other aneurysm
334.45 418.06 401.34 Hypotension
334.45 334.45 334.45 Deviated nasal septum
334.45 501.67 468.23 Other diseases of respiratory system
334.45 1254.18 1070.23 Diseases of the salivary glands
334.45 167.22 200.67 Acute and subacute necrosis of liver
334.45 334.45 334.45 Infertility, female
334.45 83.61 133.78 Ectopic pregnancy
334.45 83.61 133.78 Excessive vomiting in pregnancy
334.45 167.22 200.67 Early or threatened labor
334.45 167.22 200.67 Other and unspecified complications of the puerperium, not elsewhere classified
334.45 334.45 334.45 Crystal arthropathies
334.45 334.45 334.45 Congenital anomalies of urinary system
334.45 83.61 133.78 Congenital anomalies of the integument
334.45 83.61 133.78 Senility without mention of psychosis
334.45 83.61 133.78 Malignant neoplasm of other and unspecified parts of mouth