The Egocentric Comorbidity Network on Disorders of amino-acid transport and metabolism


Disease Info.
ICD-9: 270
Disease ID: 211
Disease Name: Disorders of amino-acid transport and metabolism
Descriptives of the sampled nested cases-control dataset
Total individual= 1405
Case:Control = 281 : 1124 ( 1 : 4 )
No. of control with zero baseline= 624
No. of select variables= 289
Messages in th clogit procedure
WARN: Loglik converged before variable 4,5,72,182 ; coefficient may be infinite.
Fitted coefficients in conditional logistic model (p<0.05 only)
*Progression links allowed are marked in red
coef exp(coef) se(coef) z Pr(>|z|) name sig
16.423 13560437.318 4.328 3.794 0.000 Deficiency of B -complex components ***
14.885 2913446.676 4.944 3.010 0.003 Other disorders of pancreatic internal secretion **
13.697 888379.836 6.976 1.963 0.050 Nonspecific findings on examination of urine *
13.128 502756.020 6.250 2.100 0.036 Malignant neoplasm of rectum, rectosigmoid junction, and anus *
12.439 252338.543 4.433 2.806 0.005 Benign neoplasm of kidney and other urinary organs **
12.275 214178.815 4.784 2.566 0.010 Transient organic psychotic conditions **
9.199 9889.254 4.087 2.251 0.024 Benign neoplasm of respiratory and intrathoracic organs *
8.624 5560.968 4.279 2.015 0.044 Arterial embolism and thrombosis *
7.314 1500.684 2.262 3.233 0.001 Purpura and other hemorrhagic conditions ***
6.739 845.097 2.289 2.945 0.003 Diseases of white blood cells **
6.268 527.428 2.767 2.265 0.023 Bullous dermatoses *
5.669 289.768 1.809 3.134 0.002 Other disorders of kidney and ureter **
4.705 110.539 1.673 2.813 0.005 Other complications of pregnancy, not elsewhere classified **
4.658 105.395 1.360 3.425 0.001 Other diseases of lung ***
4.097 60.166 1.325 3.093 0.002 Other disorders of female genital organs **
3.573 35.637 1.746 2.047 0.041 Parkinson's disease *
3.212 24.833 0.902 3.560 0.000 Hearing loss ***
2.920 18.549 0.970 3.010 0.003 Obesity and other hyperalimentation **
2.788 16.254 0.777 3.590 0.000 Ovarian dysfunction ***
2.673 14.481 1.071 2.495 0.013 Erythematosquamous dermatosis *
2.515 12.365 1.098 2.290 0.022 Other perinatal jaundice *
2.468 11.795 0.834 2.958 0.003 Other derangement of joint **
2.243 9.420 1.096 2.046 0.041 Other and unspecified disorders of metabolism *
2.237 9.361 1.069 2.092 0.036 Infantile cerebral palsy *
1.870 6.488 0.816 2.292 0.022 Benign neoplasm of ovary *
1.845 6.329 0.924 1.996 0.046 Duodenal ulcer *
1.644 5.173 0.674 2.440 0.015 Angina pectoris *
1.535 4.639 0.416 3.687 0.000 Disorders of lipoid metabolism ***
1.215 3.369 0.562 2.161 0.031 Asthma *
1.085 2.959 0.442 2.453 0.014 Diabetes mellitus *
1.021 2.775 0.520 1.963 0.050 Cataract *
0.969 2.634 0.441 2.199 0.028 Chronic pharyngitis and nasopharyngitis *
0.839 2.315 0.345 2.431 0.015 Disorders of menstruation and other abnormal bleeding from female genital tract *
0.784 2.191 0.348 2.252 0.024 General symptoms *
-0.806 0.447 0.364 -2.215 0.027 Contact dermatitis and other eczema *
-1.388 0.249 0.491 -2.830 0.005 Other disorders of urethra and urinary tract **
-1.458 0.233 0.740 -1.970 0.049 Uterine leiomyoma *
-1.462 0.232 0.549 -2.661 0.008 Disorders of refraction and accommodation **
-1.568 0.208 0.719 -2.180 0.029 Disorders of muscle, ligament and fascia *
-1.636 0.195 0.800 -2.046 0.041 Noninflammatory disorders of cervix *
-2.556 0.078 1.087 -2.351 0.019 Other hypertrophic and atrophic conditions of skin *
-2.923 0.054 0.930 -3.142 0.002 Other retinal disorders **
-6.477 0.002 2.660 -2.435 0.015 Hypertensive heart and renal disease *
-6.486 0.002 2.245 -2.889 0.004 Other extrapyramidal disease and abnormal movement disorders **
-8.371 0.000 4.209 -1.989 0.047 Other disorders of arteries and arterioles *
-10.264 0.000 3.353 -3.061 0.002 Benign neoplasm of other parts of digestive system **
-11.187 0.000 4.986 -2.244 0.025 Malignant neoplasm of colon *
-16.885 0.000 4.038 -4.182 0.000 Other deficiency anemias ***
Age distribution of cases
Prevalence of exposure in the dataset per 100,000
*marked green when case > control
case control overall name
58362.99 24733.10 31459.07 General symptoms
52313.17 25355.87 30747.33 Gingival and periodontal diseases
50533.81 23843.42 29181.49 Diseases of hard tissues of teeth
44839.86 17704.63 23131.67 Functional digestive disorders, not elsewhere classified
42348.75 17882.56 22775.80 Contact dermatitis and other eczema
42348.75 18594.31 23345.20 Symptoms involving head and neck
41281.14 18950.18 23416.37 Other disorders of soft tissues
40925.27 20907.47 24911.03 Other and unspecified disorders of back
40213.52 19839.86 23914.59 Gastritis and duodenitis
39145.91 14768.68 19644.13 Symptoms involving respiratory system and other chest symptoms
38434.16 16192.17 20640.57 Other symptoms involving abdomen and pelvis
37010.68 15480.43 19786.48 Disorders of function of stomach
36654.80 14857.65 19217.08 Inflammatory disease of cervix, vagina and vulva
34163.70 10943.06 15587.19 Disorders of lipoid metabolism
32740.21 15480.43 18932.38 Osteoarthrosis and allied disorders
32384.34 15124.56 18576.51 Essential hypertension
30960.85 14679.72 17935.94 Diseases of pulp and periapical tissues
29893.24 13434.16 16725.98 Other noninfectious gastroenteritis and colitis
29537.37 11121.00 14804.27 Other and unspecified disorder of joint
27758.01 9341.64 13024.91 Disorders of menstruation and other abnormal bleeding from female genital tract
25266.90 11032.03 13879.00 Diseases of the oral soft tissues, excluding lesions specific for gingiva and tongue
24555.16 11387.90 14021.35 Peptic ulcer, site unspecified
23487.54 12633.45 14804.27 Neurotic disorders
23487.54 11298.93 13736.65 Other disorders of urethra and urinary tract
23487.54 10053.38 12740.21 Other disorders of synovium, tendon and bursa
23131.67 11832.74 14092.53 Menopausal and postmenopausal disorders
22775.80 7295.37 10391.46 Symptoms involving digestive system
22419.93 8451.96 11245.55 Diabetes mellitus
21352.31 6227.76 9252.67 Allergic rhinitis
20996.44 7473.31 10177.94 Chronic liver disease and cirrhosis
19217.08 10587.19 12313.17 Spondylosis and allied disorders
18861.21 8896.80 10889.68 Cataract
18505.34 9252.67 11103.20 Hypertensive heart disease
17793.59 5871.89 8256.23 Chronic pharyngitis and nasopharyngitis
17793.59 8362.99 10249.11 Pruritus and related conditions
17793.59 9875.44 11459.07 Peripheral enthesopathies and allied syndromes
16725.98 7295.37 9181.49 Urticaria
15658.36 5338.08 7402.14 Other diseases of upper respiratory tract
15302.49 6583.63 8327.40 Other forms of chronic ischemic heart disease
14946.62 7651.25 9110.32 Vertiginous syndromes and other disorders of vestibular system
14946.62 5427.05 7330.96 Symptoms involving cardiovascular system
14590.75 4359.43 6405.69 Gout
14234.88 8274.02 9466.19 Other disorders of bone and cartilage
13523.13 5782.92 7330.96 Dermatophytosis
13167.26 4626.33 6334.52 Diseases of esophagus
12811.39 7651.25 8683.27 Other and unspecified arthropathies
12811.39 4359.43 6049.82 Intervertebral disc disorders
12455.52 5249.11 6690.39 Asthma
12099.64 4181.49 5765.12 Disorders of lacrimal system
11743.77 2758.01 4555.16 Other and unspecified anemias
11387.90 4804.27 6121.00 Cardiac dysrhythmias
11387.90 3825.62 5338.08 Symptoms involving skin and other integumentary tissue
10676.16 6227.76 7117.44 Other diseases and conditions of the teeth and supporting structures
10320.28 4982.21 6049.82 Disorders of refraction and accommodation
10320.28 5249.11 6263.35 Chronic bronchitis
9964.41 4181.49 5338.08 Special symptoms or syndromes not elsewhere classified
9964.41 5071.17 6049.82 Gastric ulcer
9964.41 4715.30 5765.12 Other disorders of cervical region
9964.41 4181.49 5338.08 Symptoms involving urinary system
9252.67 4448.40 5409.25 Visual disturbances
9252.67 4982.21 5836.30 Disorders of muscle, ligament and fascia
8896.80 4181.49 5124.56 Other disorders of breast
8896.80 3736.65 4768.68 Diseases of sebaceous glands
8540.93 2669.04 3843.42 Angina pectoris
8185.05 3380.78 4341.64 Other retinal disorders
8185.05 2846.98 3914.59 Other disorders of skin and subcutaneous tissue
7829.18 2224.20 3345.20 Uterine leiomyoma
7829.18 3558.72 4412.81 Hemorrhoids
7473.31 2846.98 3772.24 Benign neoplasm of breast
7473.31 2313.17 3345.20 Mononeuritis of upper limb and mononeuritis multiplex
7473.31 1601.42 2775.80 Suppurative and unspecified otitis media
7117.44 1601.42 2704.63 Nerve root and plexus disorders
6761.57 1690.39 2704.63 Viral hepatitis
6405.69 889.68 1992.88 Iron deficiency anemias
6405.69 2669.04 3416.37 Other disorders of eyelids
6405.69 3291.81 3914.59 Other disorders of eye
6049.82 2135.23 2918.15 Herpes zoster
6049.82 2046.26 2846.98 Noninflammatory disorders of cervix
6049.82 622.78 1708.19 Other derangement of joint
6049.82 889.68 1921.71 Ankylosing spondylitis and other inflammatory spondylopathies
5693.95 2669.04 3274.02 Benign neoplasm of skin
5693.95 2758.01 3345.20 Heart failure
5693.95 622.78 1637.01 Nonspecific abnormal results of function studies
5338.08 2491.10 3060.50 Glaucoma
5338.08 1423.49 2206.41 Hearing loss
5338.08 1245.55 2064.06 Chronic sinusitis
5338.08 1423.49 2206.41 Other disorders of liver
5338.08 2313.17 2918.15 Other diseases due to viruses and Chlamydiae
5338.08 800.71 1708.19 Endometriosis
4982.21 978.65 1779.36 Nonsuppurative otitis media and eustachian tube disorders
4982.21 1690.39 2348.75 Pain and other symptoms associated with female genital organs
4982.21 2046.26 2633.45 Atopic dermatitis and related conditions
4982.21 1423.49 2135.23 Rheumatoid arthritis and other inflammatory polyarthropathies
4626.33 800.71 1565.84 Benign neoplasm of ovary
4626.33 1423.49 2064.06 Simple and unspecified goiter
4626.33 2313.17 2775.80 Physiological malfunction arising from mental factors
4626.33 711.74 1494.66 Regional enteritis
4626.33 800.71 1565.84 Nonspecific findings on examination of blood
4270.46 1334.52 1921.71 Thyrotoxicosis with or without goiter
4270.46 2046.26 2491.10 Migraine
4270.46 2758.01 3060.50 Other diseases of endocardium
4270.46 2935.94 3202.85 Candidiasis
3914.59 711.74 1352.31 Neoplasm of unspecified nature
3914.59 622.78 1281.14 Ovarian dysfunction
3914.59 533.81 1209.96 Other and unspecified disorders of metabolism
3914.59 177.94 925.27 Epilepsy
3914.59 3558.72 3629.89 Other disorders of ear
3914.59 1690.39 2135.23 Other and ill-defined cerebrovascular disease
3914.59 1512.46 1992.88 Noninflammatory disorders of vagina
3914.59 800.71 1423.49 Dermatitis due to substances taken internally
3558.72 1067.62 1565.84 Group B streptococcus infections of unspecified site
3558.72 889.68 1423.49 Ill-defined descriptions and complications of heart disease
3558.72 800.71 1352.31 Dentofacial anomalies, including malocclusion
3558.72 3291.81 3345.20 Duodenal ulcer
3202.85 889.68 1352.31 Nontoxic nodular goiter
3202.85 1245.55 1637.01 Other disorders of intestine
3202.85 978.65 1423.49 Chronic renal failure
2846.98 533.81 996.44 Other peripheral vascular disease
2846.98 711.74 1138.79 Hemorrhage in early pregnancy
2846.98 800.71 1209.96 Erythematosquamous dermatosis
2846.98 622.78 1067.62 Other hypertrophic and atrophic conditions of skin
2846.98 1067.62 1423.49 Disorders of sweat glands
2846.98 978.65 1352.31 Diffuse diseases of connective tissue
2491.10 177.94 640.57 Obesity and other hyperalimentation
2491.10 88.97 569.40 Purpura and other hemorrhagic conditions
2491.10 1156.58 1423.49 Senile and presenile organic psychotic conditions
2491.10 1512.46 1708.19 Affective psychoses
2491.10 444.84 854.09 Disorders of optic nerve and visual pathways
2491.10 711.74 1067.62 Herpes simplex
2491.10 711.74 1067.62 Acute, but ill-defined, cerebrovascular disease
2491.10 1601.42 1779.36 Late effects of cerebrovascular disease
2491.10 711.74 1067.62 Other disorders of circulatory system
2491.10 2135.23 2206.41 Chronic airways obstruction, not elsewhere classified
2491.10 622.78 996.44 Other disorders of kidney and ureter
2491.10 711.74 1067.62 Diseases of hair and hair follicles
2491.10 355.87 782.92 Chronic ulcer of skin
2491.10 711.74 1067.62 Internal derangement of knee
2135.23 889.68 1138.79 Other benign neoplasm of uterus
2135.23 266.90 640.57 Acquired hypothyroidism
2135.23 88.97 498.22 Infantile cerebral palsy
2135.23 978.65 1209.96 Inflammatory and toxic neuropathy
2135.23 266.90 640.57 Hypertensive renal disease
2135.23 711.74 996.44 Disorders of tooth development and eruption
2135.23 266.90 640.57 Disorders resulting from impaired renal function
2135.23 622.78 925.27 Disorders of uterus, not elsewhere classified
2135.23 88.97 498.22 Other complications of pregnancy, not elsewhere classified
2135.23 711.74 996.44 Other congenital musculoskeletal anomalies
2135.23 978.65 1209.96 Symptoms involving nervous and musculoskeletal systems
1779.36 444.84 711.74 Other benign neoplasm of connective and other soft tissue
1779.36 355.87 640.57 Benign neoplasm of brain and other parts of nervous system
1779.36 266.90 569.40 Carcinoma in situ of breast and genitourinary system
1779.36 533.81 782.92 Other organic psychotic conditions (chronic)
1779.36 711.74 925.27 Parkinson's disease
1779.36 88.97 427.05 Other conditions of brain
1779.36 266.90 569.40 Mononeuritis of lower limb
1779.36 800.71 996.44 Corneal opacity and other disorders of cornea
1779.36 88.97 427.05 Liver abscess and sequelae of chronic liver disease
1779.36 355.87 640.57 Other disorders of female genital organs
1779.36 88.97 427.05 Normal delivery
1423.49 889.68 996.44 Other disorders of thyroid
1423.49 177.94 427.05 Disorders of the pituitary gland and its hypothalamic control
1423.49 177.94 427.05 Transient organic psychotic conditions
1423.49 622.78 782.92 Depressive disorder, not elsewhere classified
1423.49 88.97 355.87 Hyperkinetic syndrome of childhood
1423.49 355.87 569.40 Hemiplegia and hemiparesis
1423.49 711.74 854.09 Hereditary and idiopathic peripheral neuropathy
1423.49 266.90 498.22 Myoneural disorders
1423.49 533.81 711.74 Disorders of the globe
1423.49 711.74 854.09 Coronary occlusion without myocardial infarction
1423.49 266.90 498.22 Other venous embolism and thrombosis
1423.49 88.97 355.87 Varicose veins of other sites
1423.49 622.78 782.92 Chronic disease of tonsils and adenoids
1423.49 266.90 498.22 Other diseases of lung
1423.49 622.78 782.92 Diseases of the salivary glands
1423.49 622.78 782.92 Nephrotic syndrome
1423.49 711.74 854.09 Chronic glomerulonephritis
1423.49 711.74 854.09 Nephritis and nephropathy, not specified as acute or chronic
1423.49 800.71 925.27 Other disorders of bladder
1423.49 355.87 569.40 Noninflammatory disorders of ovary, fallopian tube and broad ligament
1423.49 533.81 711.74 Viral and chlamydial infection in conditions classified elsewhere and of unspecified site
1423.49 444.84 640.57 Infertility, female
1423.49 177.94 427.05 Psoriasis and similar disorders
1423.49 711.74 854.09 Other dermatoses
1423.49 355.87 569.40 Late effects of tuberculosis
1067.62 444.84 569.40 Malignant neoplasm of colon
1067.62 177.94 355.87 Secondary and unspecified malignant neoplasm of lymph nodes
1067.62 88.97 284.70 Secondary malignant neoplasm of other specified sites
1067.62 88.97 284.70 Benign neoplasm of lip, oral cavity and pharynx
1067.62 88.97 284.70 Benign neoplasm of respiratory and intrathoracic organs
1067.62 88.97 284.70 Other disorders of pancreatic internal secretion
1067.62 266.90 427.05 Disorders of adrenal glands
1067.62 355.87 498.22 Other endocrine disorders
1067.62 444.84 569.40 Other deficiency anemias
1067.62 177.94 355.87 Hereditary hemolytic anemias
1067.62 533.81 640.57 Other extrapyramidal disease and abnormal movement disorders
1067.62 266.90 427.05 Retinal detachments and defects
1067.62 88.97 284.70 Strabismus and other disorders of binocular eye movements
1067.62 444.84 569.40 Hypertensive heart and renal disease
1067.62 444.84 569.40 Atherosclerosis
1067.62 444.84 569.40 Varicose veins of lower extremities
1067.62 355.87 498.22 Hypotension
1067.62 444.84 569.40 Other diseases of respiratory system
1067.62 177.94 355.87 Anal fissure and fistula
1067.62 355.87 498.22 Excessive vomiting in pregnancy
1067.62 88.97 284.70 Other current conditions in the mother classifiable elsewhere, but complicating pregnancy, childbirth, or the puerperium
1067.62 355.87 498.22 Curvature of spine
1067.62 889.68 925.27 Other acquired deformity
1067.62 88.97 284.70 Other perinatal jaundice
1067.62 88.97 284.70 Nonspecific findings on examination of urine
1067.62 266.90 427.05 Other ill-defined and unknown causes of morbidity and mortality
1067.62 355.87 498.22 Acariasis
711.74 177.94 284.70 Malignant neoplasm of trachea, bronchus and lung
711.74 88.97 213.52 Malignant neoplasm of kidney and other and unspecified urinary organs
711.74 1156.58 1067.62 Benign neoplasm of other parts of digestive system
711.74 355.87 427.05 Benign neoplasm of other and unspecified sites
711.74 88.97 213.52 Neoplasm of uncertain behavior of digestive and respiratory systems
711.74 88.97 213.52 Deficiency of B -complex components
711.74 88.97 213.52 Disorders of mineral metabolism
711.74 177.94 284.70 Disorders involving the immune mechanism
711.74 177.94 284.70 Diseases of white blood cells
711.74 266.90 355.87 Schizophrenic disorders
711.74 177.94 284.70 Acute reaction to stress
711.74 444.84 498.22 Adjustment reaction
711.74 533.81 569.40 Disorders of iris and ciliary body
711.74 88.97 213.52 Chickenpox
711.74 88.97 213.52 Rheumatic diseases of aortic valve
711.74 533.81 569.40 Old myocardial infarction
711.74 88.97 213.52 Arterial embolism and thrombosis
711.74 88.97 213.52 Phlebitis and thrombophlebitis
711.74 533.81 569.40 Deviated nasal septum
711.74 355.87 427.05 Chronic laryngitis and laryngotracheitis
711.74 88.97 213.52 Diseases and other conditions of the tongue
711.74 444.84 498.22 Renal failure, unspecified
711.74 978.65 925.27 Benign mammary dysplasias
711.74 533.81 569.40 Erythematous conditions
711.74 711.74 711.74 Corns and callosities
711.74 88.97 213.52 Osteomyelitis,periostitis and other infections involving bone
711.74 88.97 213.52 Acquired deformities of toe
711.74 800.71 782.92 Dermatomycosis, other and unspecified
355.87 177.94 213.52 Malignant neoplasm of rectum, rectosigmoid junction, and anus
355.87 88.97 142.35 Malignant neoplasm of bone and articular cartilage
355.87 177.94 213.52 Malignant neoplasm of connective and other soft tissue
355.87 177.94 213.52 Other malignant neoplasm of skin
355.87 800.71 711.74 Malignant neoplasm of female breast
355.87 444.84 427.05 Malignant neoplasm of cervix uteri
355.87 88.97 142.35 Malignant neoplasm of ovary and other uterine adnexa
355.87 88.97 142.35 Malignant neoplasm of thyroid gland
355.87 88.97 142.35 Benign neoplasm of kidney and other urinary organs
355.87 266.90 284.70 Pulmonary tuberculosis
355.87 88.97 142.35 Other and unspecified protein-calorie malnutrition
355.87 88.97 142.35 Disorders of plasma protein metabolism
355.87 177.94 213.52 Other diseases of blood and blood-forming organs
355.87 88.97 142.35 Other nonorganic psychoses
355.87 88.97 142.35 Mild mental retardation
355.87 88.97 142.35 Meningitis of unspecified cause
355.87 444.84 427.05 Other cerebral degenerations
355.87 177.94 213.52 Disorders of the autonomic nervous system
355.87 622.78 569.40 Other paralytic syndromes
355.87 88.97 142.35 Trigeminal nerve disorders
355.87 355.87 355.87 Facial nerve disorders
355.87 88.97 142.35 Disorders of other cranial nerves
355.87 88.97 142.35 Other disorders of middle ear and mastoid
355.87 177.94 213.52 Other rheumatic heart disease
355.87 177.94 213.52 Chronic pulmonary heart disease
355.87 88.97 142.35 Cardiomyopathy
355.87 266.90 284.70 Conduction disorders
355.87 177.94 213.52 Polyarteritis nodosa and allied conditions
355.87 177.94 213.52 Other disorders of arteries and arterioles
355.87 800.71 711.74 Bronchiectasis
355.87 355.87 355.87 Gastrojejunal ulcer
355.87 177.94 213.52 Other disorders of stomach and duodenum
355.87 88.97 142.35 Peritonitis
355.87 355.87 355.87 Specific diseases due to Coxsackie virus
355.87 444.84 427.05 Hydronephrosis
355.87 533.81 498.22 Genital prolapse
355.87 88.97 142.35 Antepartum hemorrhage, abruptio placentae, and placenta previa
355.87 88.97 142.35 Early or threatened labor
355.87 88.97 142.35 Abnormality of organs and soft tissues of pelvis
355.87 88.97 142.35 Bullous dermatoses
355.87 177.94 213.52 Diseases of nail
355.87 88.97 142.35 Crystal arthropathies
355.87 266.90 284.70 Arthropathy associated with other disorders classified elsewhere
355.87 266.90 284.70 Polymyalgia rheumatica
355.87 355.87 355.87 Nonallopathic lesions, not elsewhere classified
355.87 88.97 142.35 Other congenital anomalies of heart
355.87 88.97 142.35 Other congenital anomalies of circulatory system
355.87 88.97 142.35 Congenital anomalies of the integument
355.87 177.94 213.52 Other nonspecific abnormal findings
355.87 355.87 355.87 Other mycoses