The Egocentric Comorbidity Network on Multiple sclerosis


Disease Info.
ICD-9: 340
Disease ID: 274
Disease Name: Multiple sclerosis
Descriptives of the sampled nested cases-control dataset
Total individual= 1135
Case:Control = 227 : 908 ( 1 : 4 )
No. of control with zero baseline= 522
No. of select variables= 236
Messages in th clogit procedure
:
Fitted coefficients in conditional logistic model (p<0.05 only)
*Progression links allowed are marked in red
coef exp(coef) se(coef) z Pr(>|z|) name sig
4.732 113.513 1.889 2.506 0.012 Hereditary and idiopathic peripheral neuropathy *
3.616 37.178 1.232 2.936 0.003 Disorders of the pituitary gland and its hypothalamic control **
3.483 32.547 1.060 3.284 0.001 Chronic glomerulonephritis ***
3.367 28.998 1.142 2.949 0.003 Other diseases of spinal cord **
3.310 27.384 1.341 2.468 0.014 Dermatitis due to substances taken internally *
3.286 26.724 1.412 2.327 0.020 Excessive vomiting in pregnancy *
3.051 21.136 1.343 2.271 0.023 Other perinatal jaundice *
3.044 20.984 0.588 5.173 0.000 Disorders of optic nerve and visual pathways ***
2.974 19.577 0.804 3.701 0.000 Diffuse diseases of connective tissue ***
2.837 17.059 1.377 2.060 0.039 Chronic renal failure *
2.768 15.932 1.117 2.478 0.013 Other conditions of brain *
2.654 14.204 0.801 3.315 0.001 Thyrotoxicosis with or without goiter ***
2.494 12.110 0.865 2.885 0.004 Symptoms involving cardiovascular system **
2.396 10.982 1.021 2.348 0.019 Acute, but ill-defined, cerebrovascular disease *
2.361 10.600 0.878 2.690 0.007 Epilepsy **
2.328 10.259 1.057 2.203 0.028 Other hypertrophic and atrophic conditions of skin *
2.261 9.593 0.947 2.388 0.017 Hemorrhoids *
2.187 8.912 0.869 2.517 0.012 Special symptoms or syndromes not elsewhere classified *
2.182 8.863 0.883 2.471 0.013 Other retinal disorders *
2.032 7.630 0.622 3.268 0.001 Intervertebral disc disorders ***
1.982 7.255 0.803 2.468 0.014 Other disorders of ear *
1.551 4.717 0.619 2.507 0.012 Disorders of lipoid metabolism *
1.179 3.252 0.502 2.349 0.019 Neurotic disorders *
1.012 2.750 0.402 2.518 0.012 Other disorders of soft tissues *
-1.113 0.329 0.463 -2.402 0.016 Diseases of pulp and periapical tissues *
-1.182 0.307 0.496 -2.385 0.017 Gastritis and duodenitis *
-1.739 0.176 0.701 -2.483 0.013 Other and unspecified disorder of joint *
-1.833 0.160 0.825 -2.221 0.026 Other diseases and conditions of the teeth and supporting structures *
-2.695 0.068 1.144 -2.355 0.019 Disorders of muscle, ligament and fascia *
-3.283 0.038 1.344 -2.443 0.015 Disorders of sweat glands *
-4.538 0.011 1.737 -2.613 0.009 Other dermatoses **
-6.325 0.002 2.396 -2.639 0.008 Other benign neoplasm of uterus **
-13.539 0.000 3.726 -3.634 0.000 Curvature of spine ***
Age distribution of cases
Prevalence of exposure in the dataset per 100,000
*marked green when case > control
case control overall name
61233.48 25770.93 32863.44 Diseases of hard tissues of teeth
61233.48 25550.66 32687.22 Gingival and periodontal diseases
59911.89 17841.41 26255.51 General symptoms
46696.04 14867.84 21233.48 Other disorders of soft tissues
44052.86 17841.41 23083.70 Disorders of menstruation and other abnormal bleeding from female genital tract
42731.28 19493.39 24140.97 Inflammatory disease of cervix, vagina and vulva
42731.28 15198.24 20704.85 Symptoms involving head and neck
41409.69 17621.15 22378.85 Contact dermatitis and other eczema
40088.11 17951.54 22378.85 Other symptoms involving abdomen and pelvis
39647.58 12444.93 17885.46 Functional digestive disorders, not elsewhere classified
37444.93 14757.71 19295.15 Gastritis and duodenitis
36563.88 12555.07 17356.83 Disorders of function of stomach
35242.29 14647.58 18766.52 Other and unspecified disorders of back
34361.23 8149.78 13392.07 Neurotic disorders
30837.00 12114.54 15859.03 Diseases of pulp and periapical tissues
30396.48 13656.39 17004.41 Symptoms involving respiratory system and other chest symptoms
29515.42 12555.07 15947.14 Other noninfectious gastroenteritis and colitis
26872.25 8039.65 11806.17 Other disorders of urethra and urinary tract
24229.07 7709.25 11013.22 Diseases of the oral soft tissues, excluding lesions specific for gingiva and tongue
22907.49 7599.12 10660.79 Allergic rhinitis
22466.96 5947.14 9251.10 Osteoarthrosis and allied disorders
20264.32 2643.17 6167.40 Visual disturbances
19383.26 6497.80 9074.89 Diseases of sebaceous glands
19383.26 5066.08 7929.52 Spondylosis and allied disorders
18942.73 6387.67 8898.68 Symptoms involving digestive system
18502.20 8590.31 10572.69 Pruritus and related conditions
18502.20 3854.63 6784.14 Intervertebral disc disorders
17621.15 6387.67 8634.36 Chronic pharyngitis and nasopharyngitis
17621.15 6828.19 8986.78 Urticaria
17180.62 3414.10 6167.40 Chronic liver disease and cirrhosis
16299.56 2312.78 5110.13 Disorders of refraction and accommodation
15859.03 4845.81 7048.46 Disorders of lipoid metabolism
15859.03 5616.74 7665.20 Menopausal and postmenopausal disorders
15418.50 7268.72 8898.68 Peptic ulcer, site unspecified
14977.97 6607.93 8281.94 Essential hypertension
14096.92 110.13 2907.49 Disorders of optic nerve and visual pathways
14096.92 3964.76 5991.19 Other disorders of breast
13656.39 4185.02 6079.30 Vertiginous syndromes and other disorders of vestibular system
13656.39 5837.00 7400.88 Peripheral enthesopathies and allied syndromes
13656.39 4845.81 6607.93 Dermatophytosis
13215.86 4625.55 6343.61 Other diseases of upper respiratory tract
13215.86 7819.38 8898.68 Other and unspecified disorder of joint
13215.86 3193.83 5198.24 Symptoms involving urinary system
12334.80 2533.04 4493.39 Other disorders of cervical region
12334.80 6167.40 7400.88 Other disorders of synovium, tendon and bursa
11894.27 2202.64 4140.97 Symptoms involving cardiovascular system
11453.74 4185.02 5638.77 Candidiasis
10572.69 1101.32 2995.59 Other disorders of eye
10132.16 1762.11 3436.12 Cataract
10132.16 2422.91 3964.76 Hemorrhoids
9691.63 550.66 2378.85 Diffuse diseases of connective tissue
9691.63 3414.10 4669.60 Disorders of muscle, ligament and fascia
9251.10 1431.72 2995.59 Special symptoms or syndromes not elsewhere classified
9251.10 1872.25 3348.02 Disorders of lacrimal system
9251.10 1982.38 3436.12 Cardiac dysrhythmias
9251.10 3414.10 4581.50 Other and unspecified arthropathies
8810.57 2863.44 4052.86 Diseases of esophagus
8810.57 3414.10 4493.39 Hemorrhage in early pregnancy
8370.04 991.19 2466.96 Mononeuritis of upper limb and mononeuritis multiplex
8370.04 2643.17 3788.55 Asthma
8370.04 4185.02 5022.03 Other disorders of skin and subcutaneous tissue
8370.04 1762.11 3083.70 Symptoms involving skin and other integumentary tissue
7929.52 1211.45 2555.07 Other retinal disorders
7929.52 3964.76 4757.71 Pain and other symptoms associated with female genital organs
7488.99 2092.51 3171.81 Benign neoplasm of skin
7488.99 2092.51 3171.81 Other and unspecified anemias
7488.99 1651.98 2819.38 Other disorders of ear
7488.99 2312.78 3348.02 Noninflammatory disorders of cervix
7488.99 2312.78 3348.02 Other disorders of bone and cartilage
7048.46 3744.49 4405.29 Diabetes mellitus
7048.46 1321.59 2466.96 Migraine
7048.46 2422.91 3348.02 Gastric ulcer
6607.93 3744.49 4317.18 Uterine leiomyoma
6607.93 1431.72 2466.96 Thyrotoxicosis with or without goiter
6167.40 1431.72 2378.85 Benign neoplasm of breast
6167.40 3083.70 3700.44 Hypertensive heart disease
6167.40 220.26 1409.69 Other and ill-defined cerebrovascular disease
6167.40 5506.61 5638.77 Other diseases and conditions of the teeth and supporting structures
6167.40 3744.49 4229.07 Noninflammatory disorders of vagina
5726.87 1211.45 2114.54 Nerve root and plexus disorders
5726.87 881.06 1850.22 Chronic sinusitis
5286.34 1431.72 2202.64 Benign neoplasm of ovary
5286.34 1321.59 2114.54 Iron deficiency anemias
5286.34 110.13 1145.37 Other diseases of spinal cord
5286.34 770.93 1674.01 Infertility, female
5286.34 1982.38 2643.17 Atopic dermatitis and related conditions
4845.81 220.26 1145.37 Facial nerve disorders
4845.81 770.93 1585.90 Glaucoma
4845.81 1982.38 2555.07 Chronic bronchitis
4845.81 660.79 1497.80 Dentofacial anomalies, including malocclusion
4845.81 770.93 1585.90 Benign mammary dysplasias
4845.81 2092.51 2643.17 Other diseases due to viruses and Chlamydiae
4845.81 770.93 1585.90 Ankylosing spondylitis and other inflammatory spondylopathies
4405.29 1431.72 2026.43 Other disorders of eyelids
4405.29 1211.45 1850.22 Nonsuppurative otitis media and eustachian tube disorders
4405.29 1541.85 2114.54 Suppurative and unspecified otitis media
4405.29 2422.91 2819.38 Other forms of chronic ischemic heart disease
4405.29 991.19 1674.01 Other diseases of endocardium
4405.29 1982.38 2466.96 Viral hepatitis
4405.29 550.66 1321.59 Other hypertrophic and atrophic conditions of skin
4405.29 1431.72 2026.43 Disorders of sweat glands
3964.76 991.19 1585.90 Neoplasm of unspecified nature
3964.76 220.26 969.16 Disorders of the pituitary gland and its hypothalamic control
3964.76 991.19 1585.90 Ovarian dysfunction
3964.76 1101.32 1674.01 Physiological malfunction arising from mental factors
3964.76 110.13 881.06 Acute, but ill-defined, cerebrovascular disease
3964.76 440.53 1145.37 Other peripheral vascular disease
3964.76 991.19 1585.90 Erythematosquamous dermatosis
3524.23 1101.32 1585.90 Simple and unspecified goiter
3524.23 550.66 1145.37 Other endocrine disorders
3524.23 1872.25 2202.64 Gout
3524.23 660.79 1233.48 Hearing loss
3524.23 770.93 1321.59 Herpes zoster
3524.23 330.40 969.16 Heart failure
3524.23 220.26 881.06 Late effects of cerebrovascular disease
3524.23 2092.51 2378.85 Duodenal ulcer
3524.23 1651.98 2026.43 Endometriosis
3524.23 991.19 1497.80 Early or threatened labor
3524.23 1321.59 1762.11 Diseases of hair and hair follicles
3083.70 991.19 1409.69 Affective psychoses
3083.70 220.26 792.95 Epilepsy
3083.70 881.06 1321.59 Disorders of tooth development and eruption
3083.70 991.19 1409.69 Other disorders of female genital organs
3083.70 881.06 1321.59 Excessive vomiting in pregnancy
3083.70 440.53 969.16 Dermatitis due to substances taken internally
3083.70 440.53 969.16 Rheumatoid arthritis and other inflammatory polyarthropathies
2643.17 550.66 969.16 Obesity and other hyperalimentation
2643.17 110.13 616.74 Other conditions of brain
2643.17 220.26 704.85 Hereditary and idiopathic peripheral neuropathy
2643.17 110.13 616.74 Coronary occlusion without myocardial infarction
2643.17 1321.59 1585.90 Angina pectoris
2643.17 330.40 792.95 Other disorders of bladder
2643.17 1101.32 1409.69 Noninflammatory disorders of ovary, fallopian tube and broad ligament
2643.17 1101.32 1409.69 Disorders of uterus, not elsewhere classified
2643.17 770.93 1145.37 Other complications of pregnancy, not elsewhere classified
2643.17 440.53 881.06 Psoriasis and similar disorders
2643.17 660.79 1057.27 Dermatomycosis, other and unspecified
2202.64 440.53 792.95 Other benign neoplasm of connective and other soft tissue
2202.64 991.19 1233.48 Nontoxic nodular goiter
2202.64 770.93 1057.27 Other disorders of thyroid
2202.64 440.53 792.95 Depressive disorder, not elsewhere classified
2202.64 110.13 528.63 Other extrapyramidal disease and abnormal movement disorders
2202.64 110.13 528.63 Hemiplegia and hemiparesis
2202.64 550.66 881.06 Mononeuritis of lower limb
2202.64 550.66 881.06 Corneal opacity and other disorders of cornea
2202.64 110.13 528.63 Other disorders of circulatory system
2202.64 660.79 969.16 Other disorders of liver
2202.64 440.53 792.95 Chronic glomerulonephritis
2202.64 330.40 704.85 Nephritis and nephropathy, not specified as acute or chronic
2202.64 991.19 1233.48 Internal derangement of knee
2202.64 440.53 792.95 Other acquired deformity
1762.11 110.13 440.53 Acquired hypothyroidism
1762.11 110.13 440.53 Inflammatory and toxic neuropathy
1762.11 110.13 440.53 Myoneural disorders
1762.11 220.26 528.63 Disorders of the globe
1762.11 220.26 528.63 Herpes simplex
1762.11 881.06 1057.27 Diseases of the salivary glands
1762.11 660.79 881.06 Other disorders of intestine
1762.11 330.40 616.74 Viral and chlamydial infection in conditions classified elsewhere and of unspecified site
1762.11 1101.32 1233.48 Other current conditions in the mother classifiable elsewhere, but complicating pregnancy, childbirth, or the puerperium
1762.11 550.66 792.95 Erythematous conditions
1762.11 881.06 1057.27 Other derangement of joint
1762.11 220.26 528.63 Nonspecific findings on examination of blood
1321.59 220.26 440.53 Malignant neoplasm of female breast
1321.59 770.93 881.06 Carcinoma in situ of breast and genitourinary system
1321.59 330.40 528.63 Senile and presenile organic psychotic conditions
1321.59 110.13 352.42 Parkinson's disease
1321.59 770.93 881.06 Group B streptococcus infections of unspecified site
1321.59 770.93 881.06 Other paralytic syndromes
1321.59 110.13 352.42 Disorders of other cranial nerves
1321.59 440.53 616.74 Chronic airways obstruction, not elsewhere classified
1321.59 330.40 528.63 Gastrojejunal ulcer
1321.59 220.26 440.53 Ectopic pregnancy
1321.59 110.13 352.42 Other fetal and placental problems affecting management of mother
1321.59 660.79 792.95 Corns and callosities
1321.59 330.40 528.63 Other congenital musculoskeletal anomalies
881.06 770.93 792.95 Benign neoplasm of other parts of digestive system
881.06 220.26 352.42 Benign neoplasm of bone and articular cartilage
881.06 1431.72 1321.59 Other benign neoplasm of uterus
881.06 110.13 264.32 Benign neoplasm of other and unspecified sites
881.06 110.13 264.32 Disorders of adrenal glands
881.06 110.13 264.32 Other deficiency anemias
881.06 330.40 440.53 Other diseases of blood and blood-forming organs
881.06 110.13 264.32 Other organic psychotic conditions (chronic)
881.06 110.13 264.32 Other nonorganic psychoses
881.06 110.13 264.32 Unspecified mental retardation
881.06 330.40 440.53 Retinal detachments and defects
881.06 220.26 352.42 Varicose veins of lower extremities
881.06 550.66 616.74 Deviated nasal septum
881.06 440.53 528.63 Chronic disease of tonsils and adenoids
881.06 110.13 264.32 Emphysema
881.06 330.40 440.53 Bronchiectasis
881.06 550.66 616.74 Other diseases of respiratory system
881.06 220.26 352.42 Diseases of the jaws
881.06 881.06 881.06 Regional enteritis
881.06 220.26 352.42 Anal fissure and fistula
881.06 220.26 352.42 Hydronephrosis
881.06 440.53 528.63 Other disorders of kidney and ureter
881.06 881.06 881.06 Genital prolapse
881.06 110.13 264.32 Noninflammatory disorders of vulva and perineum
881.06 550.66 616.74 Antepartum hemorrhage, abruptio placentae, and placenta previa
881.06 110.13 264.32 Hypertension complicating pregnancy, childbirth, and the puerperium
881.06 220.26 352.42 Other complications of labor and delivery, not elsewhere classified
881.06 220.26 352.42 Other and unspecified complications of the puerperium, not elsewhere classified
881.06 110.13 264.32 Polymyalgia rheumatica
881.06 660.79 704.85 Curvature of spine
881.06 110.13 264.32 Other perinatal jaundice
881.06 770.93 792.95 Symptoms involving nervous and musculoskeletal systems
881.06 220.26 352.42 Nonspecific abnormal results of function studies
881.06 440.53 528.63 Other mycoses
440.53 220.26 264.32 Malignant neoplasm of colon
440.53 110.13 176.21 Malignant neoplasm of liver and intrahepatic bile ducts
440.53 110.13 176.21 Hemangioma and lymphangioma, any site
440.53 110.13 176.21 Neoplasm of uncertain behavior of genitourinary organs
440.53 330.40 352.42 Thyroiditis
440.53 110.13 176.21 Disorders of carbohydrate transport and metabolism
440.53 110.13 176.21 Hereditary hemolytic anemias
440.53 220.26 264.32 Purpura and other hemorrhagic conditions
440.53 110.13 176.21 Specific nonpsychotic mental disorder due to organic brain damage
440.53 110.13 176.21 Rheumatic diseases of mitral valve
440.53 110.13 176.21 Atherosclerosis
440.53 110.13 176.21 Other disorders of arteries and arterioles
440.53 440.53 440.53 Nasal polyps
440.53 110.13 176.21 Pneumothorax
440.53 110.13 176.21 Diseases and other conditions of the tongue
440.53 110.13 176.21 Liver abscess and sequelae of chronic liver disease
440.53 220.26 264.32 Chronic renal failure
440.53 1541.85 1321.59 Normal delivery
440.53 110.13 176.21 Disproportion
440.53 1431.72 1233.48 Other dermatoses
440.53 110.13 176.21 Diseases of nail
440.53 110.13 176.21 Chronic ulcer of skin
440.53 220.26 264.32 Osteomyelitis,periostitis and other infections involving bone
440.53 220.26 264.32 Nonspecific findings on examination of urine
440.53 110.13 176.21 Other ill-defined and unknown causes of morbidity and mortality
440.53 220.26 264.32 Acariasis